To Press Releases listOct 29, 2010
The world diabetes prevalence in 2010 is estimated at 285 million, encompassing 6.4% of the global adult population. Researchers at the Nestlé Research Center in Lausanne, Switzerland, are avidly addressing this world health issue through the investigation of novel ingredients that can improve glucose control, especially for people with type 2 diabetes.
In collaboration with the Catholic University of Rome, Roma, Italy, Nestlé scientists discovered that sebacic acid, a naturally occurring 10 carbon medium-chain dicarboxylic acid, which may have positive effects on glycemic control for type 2 diabetes.
Researchers first conducted a study with people with type 2 diabetes. The men and women were given a meal containing 0g sebacic acid (control), 10g of sebacic acid in addition to the meal, or 23g of sebacic acid in substitution of fat in the meal. Researchers were interested to find that postprandial glycemia decreased by 42% in the group given the 10g sebacic acid, while the group who consumed 23g experienced a 70% decrease. Additionally, the rate of peripheral glucose appearance was significantly reduced in the 23g sebacic acid group, suggesting decreased glucose absorption and/or improved peripheral glucose uptake. The full article is available in Diabetes Care
“Though more studies are needed to demonstrate the benefit of sebacic acid on long-term glycemic control in diabetic subjects and to understand its mechanism of action, these are nevertheless exciting findings,” said Katherine Macé, Nestlé Research Center scientist. “Through our work on ingredients that may bring benefits for health, we will continue to explore nutrition solutions to help people with type 2 diabetes.”
Iaconelli A1, Gastaldelli A2, Chiellini C1, Gniuli D1, Favuzzi A1, Binnert C3, Macé K3, Mingrone G1. 1Department of Internal Medicine, Catholic University of Rome, Italy. 2Institute of Clinical Physiology, Consiglio Nazionale delle Richerche, Pisa, Italy.3Nestlé Research Center, Lausanne, Switzerland. Effect of oral sebacic acid on postprandial glycemia, insulinemia and glucose rate of appearance in type 2 diabetes. Diabetes Care. 2010 Aug 19. Epub ahead of print. doi: 10.2337
American Diabetes Association
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